Plga pla microspheres were used as an intravitreal drug delivery system. Preparation of polylacticcoglycolic acid plga nanodispersion in a yjunction microchannel. Polylactic acid polylactic coglycolic acid microparticles are among the most successful drug delivery systems. A preliminary study, journal of biomedical materials research part a on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Drugnanoencapsulated plga microspheres prepared by emulsion electrospray with controlled release behavior. Shive ms, anderson jm 1997 biodegradation and biocompatibility of pla and plga microspheres. Formulation and in vitro evaluation of alendronate sodium. Emphasis is placed on polymer and microsphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres. In plga microspheres, biodegradation controls drug release rate which was evident from the decrease of ph of dissolution medium from 6. Journal of neurology, psychiatry name of the journal journal. It was expected that presence of hydrophobic microspheres can contribute to the hydration of the scaffold thus can affect the initial phase of biodegradation but no significant difference in the rate of biodegradation was observed for first 48 hours in case of 0. Biocompatibility, biodegradation and biomedical applications.
Biodegradation and biocompatibility of contraceptive. The blend of polymers at different ratios modifies the biodegradation rates and hence their delivery profiles, for example, pga derived microspheres with different blend ratio to delivery ngf showed. Plga 5050 degrade completely after 84 days of in vitro incubation with phosphate buffered saline pbs at 37. Plgas are also known for undergoing bulk degradation in an aqueous medium.
Drugnanoencapsulated plga microspheres prepared by. Biodegradable polymers journal of excipients and food. Eeloaded plg biodegradable microspheres, and in vitro and in vivo release. Biodegradable black phosphorusbased nanospheres for in vivo. Biodegradation and biocompatibility of pla and plga microspheres, adv. Osa optical characterization and feasibility study of.
The in both plga spectrum and nanoparticles spectrum, which isassigned to one. The recent approval of new medicinal products based on plga microspheres is the proof that pharmaceutical companies have continued to exploit this drug delivery technology. Plga is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a fda approved polymer. Drugnanoencapsulated plga microspheres prepared by emulsion. Plga uniform microspheres polylacticcoglycolic acid plga is a common biodegradable polymer that has been utilized in a diverse set of medical applications. Sep 01, 2011 polyester plga is a copolymer of poly lactic acid pla and poly glycolic acid pga. Ir spectra of plga a and plgaal microspheres b results. Polysciences plga microspheres are monodisperse, and can be used as a drug encapsulant 5, a scaffold for implants and bone grafts 6. Full text development and in vitro characterization of poly.
Journal of neurology, psychiatry name of the journal. A preliminary study, journal of biomedical materials research part a. No cell death, glial activation or inflammatory reactions. Plga has excellent biodegradability and biocompatibility and is generally recognized. Dec 01, 2012 a fundamental understanding of the in vivo biodegradation phenomenon as well as an appreciation of cellular and tissue responses which determine the biocompatibility of biodegradable pla and plga microspheres are important components in the design and development of biodegradable microspheres containing bioactive agents for therapeutic application. Biocompatibility, biodegradation and excretion of polylactic acid pla in medical implants and theranostic systems article pdf available in chemical engineering journal 340 january 2018 with. In vitro and in vivo evaluations of plga microspheres. A fundamental understanding of the in vivo biodegradation phenomenon as well as an appreciation of cellular and tissue responses which determine the biocompatibility of biodegradable pla and plga microspheres are important components in the design and development of biodegradable microspheres containing bioactive agents for therapeutic application. Physical erosion mechanism a bulkeroding system pla,pga,plga, pcl degradation takes place throughout the whole of the polymer matrix. Evaluation of dosing regimen of respirable rifampicin.
Their successful performance relies on pla and plga biocompatibility and degradability characteristics. Pdf biodegradation and biocompatibility of pla and plga. Biodegradable pla or plga have been co dissolved with various biocompatible hydrophilic or amphiphilic compounds in the encapsulation procedure to prevent. Polyester plga is a copolymer of poly lactic acid pla and poly glycolic acid pga. Full text rifapentinelinezolidloaded plga microspheres. Erlotinib hcl injectable microspheres were prepared by ow emulsion solvent. Detoxification programmes seek to implement the most secure and compassionate ways of withdrawing from opiates so that the inevitable withdrawal symptoms and other complications are minimized. Plga nanoparticles formed by single or doubleemulsion with. Safety evaluation of polylacticcoglycolic acidpoly. Full text development and in vitro characterization of. Biodegradable polyd, llactidecoglycolide plga and plgabased polymeric nanoparticles are widely used for sustained release of protein and peptide drugs. Synthesis, characterization, biodegradation, and drug. Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension.
Emphasis is placed on polymer and microsphere characteristics which modulate the degradation behaviour and the foreign body reaction to the. Biodegradation study showed that incorporation of microspheres in the scaffold up to a certain extent up to 1% ww has no significant effect on early phase of degradation see figure. Chapter polylacticcoglycolic acid10 plga matrix implants joana a. Self encapsulating poly lacticcoglycolic acidplga microspheres for. Apr 16, 2019 their successful performance relies on pla and plga biocompatibility and degradability characteristics. Pdf biocompatibility, biodegradation and excretion of. The biodegradation of pla and plga based drug delivery systems. The blend of polymers at different ratios modifies the biodegradation rates and hence their delivery profiles, for example, pga derived microspheres with different blend ratio to delivery ngf showed different in vitro degradation rates. Blank and risperidoneloaded plga microspheres were fabricated by a solvent extractionevaporation method. Drug release from plga microspheres attached to solids using supercritical co2. Biodegradation and biocompatibility of pla and plga. These properties and others depend on many variables, including solvent type, feed ratios, emulsification method, and emulsifier type. Once detoxification has been achieved, the next stage is to enable the patient to overcome his or her drug addiction by ensuring consumption is permanently and completely abandoned.
The ir spectra indicatean intense peak at 1750 cm1. Polymer degradation and drug release kinetics from plga microspheres were investigated under neutral and acidic ph conditions. Plga nanoparticles formed by single or doubleemulsion. Evaluation of the biocompatibility of calcium phosphate cementplga microparticle composites. The biodegradation, biocompatibility, and tissue reaction of pla and. Ohr1031, a small molecule for the treatment of glaucoma.
The recent approval of new medicinal products based on plga. Biodegradation and biocompatibility of contraceptivesteroid. The biocompatibility of plg microspheres is shown by the results of tissue responses to plg microspheres injected intramuscularly into the thigh muscle of rats. In past two decades poly lacticcoglycolic acid plga has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. A fundamental understanding of the in vivo biodegradation phenomenon as well as an appreciation of cellular and tissue responses which determine the biocompatibility of biodegradable. The aim of this research was to formulate and evaluate injectable microspheres of erlotinib hydrochloride.
Crossref e fournier, c passirani, cn monteromenei, and jp benoit, biocompatibility of implantable synthetic polymeric drug carriers. Drug release from plga microspheres attached to solids using. Plga particles are commonly prepared by single or doubleemulsion, a method that provides the ability to customize particle characteristics such as size, encapsulant, and surface properties 7. Plga, a synthetic copolymer of poly lactic acid pla and poly glycolic. Sep 30, 2016 in this work, to accomplish high therapeutic efficacy and desirable biodegradation, poly lacticcoglycolic acid plga loaded with 3 nm bpqds is processed by an oilinwater emulsion solvent. Bioerodable plgabased microparticles for producing. Erlotinib hcl microspheres were evaluated for particle size, invitro release, invivo study, ftir, dsc, xray diffraction study. The initial burst and lag phases were similar for both ph values, while the secondary apparentzeroorder phase was. An overview of polylacticcoglycolic acid plgabased. Materials lng and ee were obtained as gifts from german remedies mumbai, india. The biocompatibility of plg microspheres is shown by the results of tissue responses to plg microspheres injected. Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig. Biodegradable polyd,llacticcoglycolic acidbased micro.
Pdf polymer biodegradation and biodegradable polymers. In past two decades poly lacticcoglycolic acid plga has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering. Plga decreases with decrease of lactic acid content in copolymer and with decrease in their molecular weight 24. Plga is synthesized by means of ringopening copolymerization of two different monomers, the cyclic dimers 1,4dioxane2,5diones of. Huiying liu, shukui yu, yuanyuan li, xiumei wang, luning wang, drug. Biocompatibility, biodegradation and biomedical applications of poly. Erlotinib hcl injectable microspheres were prepared by ow emulsion solvent evaporation technique using polycaprolactone polymer. Incorporation of salmon calcitoninloaded polylactideco. Drug release from plga microspheres attached to solids. Hu c, feng h, zhu c 2012 preparation and characterization of rifampicin plga microspheres sodium alginate in situ gel combination delivery system. Effect of acidic ph on plga microsphere degradation and release. In plga microspheres, biodegradation controls drug release rate which was evident from the decrease of ph of dissolution. Pdf polycaprolactone based injectable microspheres of.
Preparation and characterization of rifampicinplga microspheressodium alginate in situ gel combination delivery system. Preparation and characterization of estradiol valerate. Various factors can influence the biodegradation of a plga based formulation and simultaneously affect the release profile of microspheres, e. Biodegradable polyd,llacticcoglycolic acid bioline international.
Rplga and plga microspheres were prepared using rifampicin and plga 75. Accelerated polymer biodegradation of risperidone polyd. Shive, biodegradation and biocompatibility of pla and plga microspheres. Preparation of polylacticcoglycolic acidplga nanodispersion in a yjunction microchannel. Nanostructures for the engineering of cells, tissues and. Plga degrades by hydrolysis of its ester linkages, through bulk or heterogeneous erosion, in aqueous environments. Formulation and characterization of alendronate sodiumplga microspheres. Biodegradation and biocompatibility of pla and plga microspheres. Crossref e fournier, c passirani, cn monteromenei, and jp benoit. Degradation of plgaproduces some acidic products which in turn facilitates the degradation of remaining. Ribeiro1,2 1university of coimbra, coimbra, portugal.
Considering its biocompatibility and mechanical properties. The microsphere morphology and the release profiles of microspheres attached to the glass plates and to the porous alloy samples suggest that dexamethasone burst release is enhanced by plga swelling at higher co 2 pressures and better dispersion of microspheres. Ms shive and jm anderson, biodegradation and biocompatibility of pla and plga microspheres, adv drug deliv rev 1997, 28. Biodegradable black phosphorusbased nanospheres for in. Jun 11, 2019 polylactic acid polylactic coglycolic acid microparticles are among the most successful drug delivery systems. Polylactidecoglycolidebased micro and nanoparticles for the. Plga pla microspheres were injected intravitrealy into new zealand rabbits to assess the biocompatibility of these biodegradable devices, and detailed examination was performed up to 12 weeks following injection. Selfencapsulating poly lacticcoglycolic acidplga microspheres for. A fundamental understanding of the in vivo biodegradation phenomenon as well as an appreciation of cellular and tissue responses which determine the biocompatibility of biodegradable pla and plga. Hu c, feng h, zhu c 2012 preparation and characterization of. Shive institute of pathology and department of biomedical engineering, case western reserve. Volume diameter dv of the powders was obtained by laser diffraction helos particle size analysis, h0838, sympatec, gmbh. It is the best defined biomaterial available for drug delivery with respect to design and performance.
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